Pistons vs. Trail Blazers Predictions, Odds & Stats – Dec. 22

The Portland Trail Blazers (12-16) are underdogs (+6.5) as they try to extend a three-game winning streak when they host the Detroit Pistons (22-6) at 10 p.m. ET on Monday, December 22, 2025 at Moda Center. The game airs on KUNP and FDSDET.

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Listen to the game on Rip City Radio 620 Portland

Pistons vs. Trail Blazers Predictions for Monday

Our computer projection model for this matchup calls for a final score of Pistons 119, Trail Blazers 116.

  • Moneyline Pick: Pistons (-248)
  • Total Pick: Over 234.5 (computer predicts 235.2 points)
  • Pick ATS: Trail Blazers (+6.5)

Recent Pistons vs. Trail Blazers Matchups

Pistons vs Trail Blazers (Recent Matchups)
Date Favorite Spread Total Favorite Moneyline Underdog Moneyline Result
12/5/2025 Pistons -7.5 235.5 -318 +255 122-116 DET
3/9/2025 Pistons -3.5 231.5 -165 +139 119-112 DET
1/6/2025 Pistons -6.5 224 -249 +201 118-115 DET

Pistons 2025-26 Betting Trends

  • Detroit is 16-12-0 against the spread this season.
  • The Pistons have a 7-5 record against the spread this season when favored by 6.5 points or more.
  • A total of 14 of Detroit's 28 games with a set total have hit the over (50%).
  • The Pistons have entered the game as favorites 22 times this season and won 17, or 77.3%, of those games.
  • Detroit has been at least a -248 moneyline favorite 12 times this season and won all of those games.

Trail Blazers 2025-26 Betting Trends

  • So far this year, Portland has compiled a 15-13-0 record against the spread.
  • In games they have played as at least 6.5-point underdogs this season, the Trail Blazers are 5-2 against the spread.
  • A total of 18 of Portland's 28 games with a set total have hit the over (64.3%).
  • The Trail Blazers have won 41.2% of the games this season they were the moneyline underdog (7-10).
  • In games it has played as a moneyline underdog with odds of +202 or longer, Portland has a record of 2-5 (28.6%).

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Pistons vs. Trail Blazers Injury Report

Pistons

Pistons:

Ron Holland: Questionable (Knee),

Jalen Duren: Probable (Hip)

Trail Blazers

Trail Blazers:

Damian Lillard: Out For Season (Achilles),

Scoot Henderson: Out (Hamstring),

Blake Wesley: Out (Foot),

Matisse Thybulle: Out (Thumb),

Jrue Holiday: Out (Calf),

Jerami Grant: Day-To-Day (Achilles)

Pistons vs. Trail Blazers Game Time and TV Channel

  • Game day: Monday, December 22, 2025
  • Game time: 10 p.m. ET
  • TV channel: KUNP and FDSDET
  • Location: Portland, Oregon
  • Arena: Moda Center
  • Live stream: Watch this game on Fubo (Regional restrictions may apply)

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