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Which team is going to emerge victorious on Sunday, Nov. 16, when the San Francisco 49ers and Arizona Cardinals go head to head at 4:05 p.m. ET? Our projection model sides with the 49ers. Dive into our other projections below, where we break down the final score, spread, and over/under.
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49ers vs. Cardinals Game Info and TV Channel
- When: Sunday, November 16, 2025 at 4:05 p.m. ET
- Where: State Farm Stadium in Glendale, Arizona
- TV: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Listen to the game on 107.7 The Bone
49ers vs. Cardinals Odds and Betting Info
- Spread favorite: 49ers (-3.5)
- Moneyline: 49ers (-190), Cardinals (+158)
- Total: 48.5 points
49ers vs. Cardinals Prediction
- Pick ATS: 49ers (-3.5)
- Pick OU: Under (48.5)
Prediction:
49ers 25 - Cardinals 20
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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49ers vs. Cardinals Betting Insights
- The 49ers are 5-5-0 ATS this season.
- The Cardinals have won five games against the spread this year, failing to cover four times.
- Arizona has an ATS record of 4-2 when playing as at least 3.5-point underdogs this year.
- The 49ers and their opponent have combined to go over the point total six out of 10 times this season.
- The Cardinals and their opponent have combined to go over the point total five out of nine times this season.
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