Photo: Alika Jenner / Getty Images Sport / Getty Images
The Minnesota Timberwolves take the court against the Portland Trail Blazers as 3.5-point favorites in the first game of the 2025-26 NBA season for both teams on Wednesday, October 22, 2025 at 10 p.m. ET on KUNP and FDSN.
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Listen to the game on Rip City Radio 620 Portland
Timberwolves vs. Trail Blazers Predictions for Wednesday
Our computer model for this matchup expects a final score of Timberwolves 115, Trail Blazers 109.
- Moneyline Pick: Timberwolves (-165)
- Total Pick: Over 220.5 (computer predicts 223.5 points)
- Pick ATS: Timberwolves (-3.5)
Recent Timberwolves vs. Trail Blazers Matchups
| Date | Favorite | Spread | Total | Favorite Moneyline | Underdog Moneyline | Result |
|---|---|---|---|---|---|---|
| 2/8/2025 | Timberwolves | -3.5 | 212.5 | -163 | +137 | 114-98 MIN |
| 11/13/2024 | Timberwolves | -10 | 220 | -510 | +383 | 106-98 POR |
| 11/12/2024 | Timberwolves | -9.5 | 221.5 | -424 | +326 | 122-108 POR |
| 11/8/2024 | Timberwolves | -12 | 219.5 | -735 | +513 | 127-102 MIN |
Timberwolves 2024-25 Betting Trends
- Minnesota was 39-43-0 against the spread last year.
- Against the spread, as 3.5-point favorites or greater, the Timberwolves went 21-30 last year.
- Out of 82 Minnesota games last season, 44 went over the total.
- The Timberwolves finished 40-23 in games they were favored on the moneyline last season (winning 63.5% of those games).
- When it played as a moneyline favorite with odds of -165 or shorter last year, Minnesota finished with a record of 31-16 (66%).
Trail Blazers 2024-25 Betting Trends
- Portland covered 46 times in 82 chances against the spread last year.
- The Trail Blazers went 34-27 as underdogs of 3.5 points or more last season.
- Portland and its opponent combined to go over the point total 40 out of 82 times last year.
- The Trail Blazers were underdogs 69 times last season and won 26, or 37.7%, of those games.
- Portland had a record of 19-38, a 33.3% win rate, when it was set as the underdog by +139 or more by bookmakers last season.
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Timberwolves vs. Trail Blazers Injury Report
Timberwolves
Timberwolves:
Leonard Miller: Out (Finger),
Anthony Edwards: Day-To-Day (Back)
Trail Blazers
Trail Blazers:
Scoot Henderson: Out (Hamstring),
Damian Lillard: Out For Season (Achilles),
Robert Williams III: Out (Reconditioning)
Timberwolves vs. Trail Blazers Game Time and TV Channel
- Game day: Wednesday, October 22, 2025
- Game time: 10 p.m. ET
- TV channel: KUNP and FDSN
- Location: Portland, Oregon
- Arena: Moda Center
- Live stream: Watch this game on Fubo (Regional restrictions may apply)
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